Accelerating Materials Innovation
Result of the Month (ROM), December2023
"Direct observation of glycans bonded to proteins and lipids at the single-molecule level"
Proteins and lipids decorated with glycans are found throughout biological entities, playing roles in biological functions and dysfunctions. Current analytical strategies for these glycan-decorated biomolecules, termed glycoconjugates, rely on ensemble-averaged methods that do not provide a full view of positions and structures of glycans attached at individual sites in a given molecule, especially for glycoproteins. We show single-molecule analysis of glycoconjugates by direct imaging of individual glycoconjugate molecules using low-temperature scanning tunnelling microscopy. Intact glycoconjugate ions from electrospray are soft-landed on a surface for their direct single-molecule imaging. The submolecular imaging resolution corroborated by quantum mechanical modeling unveils whole structures and attachment sites of glycans in glycopeptides, glycolipids, N-glycoproteins, and O-glycoproteins densely decorated with glycans.
Scienta Omicron Newsflyer Spring 2023
The Scienta Omicron Spring Newsflyer is finally here and this year we have a lot to celebrate together with you!
Scienta Omicron recently reached a milestone in the company’s’ history; we shipped our 1000th system (and we don´t include bolt-on SPM microscopes, or analysers in that number!). We are humbled by the thought that our instruments, placed all over the world, have now reached this respectable number. But furthermore, the Scienta part of Scienta Omicron is turning 40 years old this year. This edition of the Scienta Omicron Spring Newsflyer contains more information about these two major events and much more!
News PEAK-1.5 Now Available for Download!
We're thrilled to announce that PEAK-1.5 is now ready for download at the Scienta Omicron Customer Portal. Here's a quick overview of the new features you can expect with this release:
- New Sequence Control for easier setup of measurements
- A fresh Sequence View with Spectrum Region Summaries for better control during measurement
- Introduction of Continuous Pass Energies for optimisation of instrument resolution and data recording efficiency (requires a new software license)
- Introduction of a Detector Overexposure Monitor to protect the MCP/CMOS detector from intensity overload
Open and Closed Cycle Sample Manipulators
When aiming at high experimental energy resolution for ARPES measurement, it is crucial to achieve ultra-low sample temperatures to quench thermal broadening. This is possible with state-of-the-art cryo manipulators reaching sample temperatures from < 3.5 K and featuring up to 6 fully motorized axes for a large range of movements. The manipulators are available as open and closed cycle. Open cycle manipulators reach lower temperature specifications and are rapidly cooled down from room temperature to 10 K in 15 min. The low He consumption below 1 l/h at ultimate temperature and the possibility to operate with liquid nitrogen at higher temperatures ensure a low operating cost. Closed cycle manipulators have no He consumption providing unlimited holding time.
PEAK Slit Control
Optimal analyser settings with remote control
In photoelectron spectroscopy measurements, there is always a trade-off between signal intensity and resolution. Optimising this balance is the key to obtaining smooth and sharp spectra within the shortest time possible. For hemispherical analysers, this trade-off is controlled by the selected entrance slit and pass energy.
PEAK Slit Control replaces manual slit changes at the analyser with a motorised and software-controlled slit. With the control of all analyser settings, easy and quick optimisation of signal intensity versus resolution is possible.
Scienta Omicron is a leading innovator in Surface Science and Nanotechnology. At our technology centres in Uppsala, Sweden and Taunusstein, Germany we develop and produce high-tech instruments. Our instruments support top researchers globally and are serviced by our four regional hubs in USA, China, Japan and Germany.
We provide state of the art instruments in Electron Spectroscopy, Scanning Probe Microscopy and Thin Film Deposition. Focusing on the race for new unique materials and solutions, in areas like – smarter batteries, next generation electronics, quantum technologies, solar energy, intelligent sensors and advanced materials, Scienta Omicron enables development of tomorrow´s materials.
THE SCIENTA GROUP: One Group, Two Leading Brands
Since 1983 the combined companies, including Scienta Omicron and Scienta Envinet (former Scienta Sensor Systems and Envinet GmbH respectively) that make up the Scienta Scientific Group have been leading the development of ultra high vacuum research and analysis equipment in the fields of Surface Science, Material Physics, UHV technology and Radiation Detection, resulting in scientific breakthroughs, Nobel Prizes and outstanding industrial equipment.